The immediate assessment of response to therapy is most beneficial to ovarian cancer patients. This study shows the correlation of drug-induced caspase activation determined by Western blot analysis and by the Caspase-Glo™ Assay. Our initial research demonstrates that the Caspase-Glo™ Assay provides a simple, fast and sensitive alternative for the evaluation of in vitro response to cytotoxic agents. The clinical correlation of caspase activity and response to treatment is under investigation.
Promega Notes 87, 15–17.
Ayesha B. Alvero and Gil Mor