The ADCC Reporter Bioassay is ideal for quantifying Fc effector function of therapeutic antibodies, as measured by activation of NFAT signaling. The assay is based on ADCC mechanism of action, and is easier to use and less variable than classic ADCC assays.
Our wide selection of bioluminescent enzyme substrates for proteases and metabolic enzymes such as CYPs and MAO, among others, provide powerful tools for the ADME-Tox screen.
Get more data in less time when you multiplex cell health biomarkers. Measure one or multiple biomarkers in vitro or in situ to detect early or late events of apoptosis and get a quick status update on targeted cells.
Easily compare the number of live cells/number of dead cells in a single well to get better consistency of data. Normalized data allows data to be easily compared from well-to-well, plate-to-plate and day-to-day.
Advance your discovery programs by using research-grade materials built on the proven and versatile luciferase reporter systems and HaloTag® labeling technologies.
Promega offers multiple readouts for quantifying cytotoxicity, including luminescent and fluorescent assays that can be multiplexed with apoptosis or viability assays to help determine mechanism of cell death.
Promega offers assays for detecting glutathione, measuring the ratio of reduced to oxidized glutathione and detecting changes in ROS as an indicator of cell health or cell signaling events.
Obtain better dynamic range and more biologically relevant data with the easy-to-use GloSensor™ assay format for live cell analysis.
Simple, "add-mix-measure" luminescent assays for detecting HDAC and Sirtuin enzyme activities.
NAD+, NADP+, NADH and NADPH are important cofactors for many enzymes involved in key cellular pathways, and quantitation of these dinucleotides is a standard approach to monitor enzyme activity directly or indirectly. Promega offers a number of systems to detect and quantify these important molecules.
Follow nuclear receptor pathways with tools ranging from specific expression vectors to cell lines engineered to express your receptor of interest.
Bioluminescent, homogeneous protease assays provide rapid, simple and sensitive measurement of protease activities directly from the cellular environment. Maximum sensitivity can be reached within 10–30 minutes of reagent addition, making these assays ideal for HTS applications.
Count on minimal interference from screening your compound library with luminescent, ATP-based kinase assays. These sensitive and reliable assays are easily scaled to meet your throughput needs.